Coming from the North:
From the motorway A1 Milan - Rome take the exit at Firenze Certosa and follow directions to Siena. When you see the exit for Siena take the exit Siena Sud, at the roundabout keep right and follow the direction to Buonconvento. At the first traffic light (see No 1 on the map) turn left and follow the sign to Porta Pispini, at the second traffic light (see No 2 on the map) turn right and at via Girolamo Gigli before crossing with via Aretina you find the Hotel Alex on the right handside.
Coming from the South:
From the motorway A1 Rome - Milan, take the exit Valdichiana, and follow the sign for the road Bettolle - Siena (E78). When you are in Siena follow the sign for the centre and go straight a head at the first roundaboat, take the left at the second roundabout and you are in via Aretina. Follow the indications to Porta Pispini and when you see Porta Pispini in front of you, Hotel Alex is in the street on your left, called Via Girolamo Gigli.